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(2017) discovered the occurrence of ferroptosis in HH using diet-induced and transgenic mice

The intergenic HBS1L-MYB region contains MYB enhancer sites and DNA targets for erythroid transcription factors [39]

With new clinical trials of APR-246 commencing in multiple tumour streams 2 , our discovery of SLC7A11 expression as a robust companion biomarker, in addition to mut-p53 status, for APR-246, may facilitate selection and enrichment of patients with mut-p53 tumours who are most likely to respond to APR-246 therapy